Frequently asked questions

FoundationOne® and FoundationOne® Heme identify and report genomic alterations that can guide informed treatment recommendations for targeted therapies, either approved or in clinical trials. They identify alterations within hundreds of relevant cancer genes with extremely high sensitivity and specificity.

FoundationOne® is available for any patient with a malignant solid tumour. It may reveal additional relevant treatment options to consider based on the molecular profile of the tumour or may help provide additional information for patients who are searching for clinical trial options.

FoundationOne® Heme is available for patients with hematologic malignancies and sarcomas. It may reveal additional treatment options to consider based on the genomic factors driving a patient's cancer.

FoundationOne®  utilises routine formalin-fixed paraffin-embedded (FFPE) clinical samples, which may be available from a previous biopsy or surgery. We have made the ordering process as simple as possible. The ordering process may differ across countries — please click here  for more ordering information specific to your country.

FoundationOne® requires 40 \\0x03BCm of FFPE tissue, of which ~20% or more is of malignant origin, on 8 to 10 unstained slides or from a block reviewed and approved by a pathologist as the most representative block for the patient diagnosis. All solid tumour types are acceptable. Click here  to download detailed specimen requirements.

Foundation Medicine is able to process any clinical sample that meets these guidelines. Should your sample be insufficient, we will notify you within approximately two days of receipt.

FoundationOne®  Heme utilises both routine FFPE samples, which may be available from a previous biopsy or surgery, and peripheral whole blood or bone marrow aspirate specimens. We have made the ordering process as simple as possible. If you are submitting an FFPE sample, all your office needs to do is complete a requisition form and ask pathology to send the sample. For peripheral whole blood or bone marrow aspirate samples, complete a requisition form and send it along with the liquid specimen. For details on sample preperation click here . The ordering process may differ across countries — please click here  for more ordering information specific to your country.

For FFPE specimens, FoundationOne® Heme requires 80 \\0x03BCm of tissue from a block reviewed and approved by a pathologist as the most representative block for the patient’s diagnosis. Click here  to download detailed specimen requirements for FFPE.

Foundation Medicine is able to process any clinical sample that meets these guidelines. Should your sample be insufficient, we will notify you within approximately two days of receipt.

Your office will receive a report 11–14 days after Foundation Medicine receives your patient's sample for FoundationOne®. The turnaround time may be slightly longer for FoundationOne® Heme. Please note this does not include the time taken to retrieve and send the sample to FMI.

We will send the results via e-mail, and you may also access reports and links to additional information through the Interactive Cancer Explorer. This secure, online resource provides current information about genomic alterations, associated therapies and clinical trials; all curated by genomic experts in oncology and pathology. It connects directly to resources like ClinicalTrials.govPubMed and other online references to give you the supporting information you need to make treatment recommendations tailored to each patient.

The Interactive Cancer Explorer is available for ordering physicians. Please contact your Roche sales representative or call Client Services at +65 6880 5399 to set up your Interactive Cancer Explorer account.

No, these tests were not designed to predict response to chemotherapy or recurrence. They help match the genomic alterations present in a cancer with specific targeted therapies either approved and launched or being investigated in clinical trials.

You may contact the Roche Molecular Information APAC Customer Services Team:

Phone: +65 6880 5399

Email: APAC.foundation@roche.com

Operating hours: Monday through Friday, 8AM to 5PM (Singapore Time)